Prieto, D., Carpena Garcia, N. , Maneu, V., Gil, M. L., Pla, J. and Gozalbo, D. (2016) TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model. Microbes and Infection, 18(10), pp. 656-660. (doi: 10.1016/j.micinf.2016.05.005) (PMID:27256463)
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Abstract
Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2−/− mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2−/− mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2−/− mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Carpena Garcia, Miss Nuria |
| Authors: | Prieto, D., Carpena Garcia, N., Maneu, V., Gil, M. L., Pla, J., and Gozalbo, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Microbes and Infection |
| Publisher: | Elsevier |
| ISSN: | 1286-4579 |
| ISSN (Online): | 1769-714X |
| Published Online: | 30 May 2016 |
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