An oligofluorene truxene based distributed feedback laser for biosensing applications

Haughey, A.-M., Guilhabert, B., Kanibolotsky, A. L., Skabara, P. J. , Dawson, M. D., Burley, G. A. and Laurand, N. (2014) An oligofluorene truxene based distributed feedback laser for biosensing applications. Biosensors and Bioelectronics, 54, pp. 679-686. (doi: 10.1016/j.bios.2013.11.054) (PMID:24355421)

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Abstract

The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein–small molecule interaction is reported. The protein avidin was detected down to 1 μg mL -1 using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to 50; 000 μg mL -1. Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable.

Item Type:Articles
Additional Information:The authors gratefully acknowledge financial support by the EPSRC (EP/J021962/1 and EP/I029141/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Skabara, Professor Peter and Burley, Dr Glenn
Authors: Haughey, A.-M., Guilhabert, B., Kanibolotsky, A. L., Skabara, P. J., Dawson, M. D., Burley, G. A., and Laurand, N.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Biosensors and Bioelectronics
Publisher:Elsevier
ISSN:0956-5663
ISSN (Online):1873-4235
Published Online:25 November 2013

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