A guide to chemokines and their receptors

Hughes, C. E. and Nibbs, R. J.B. (2018) A guide to chemokines and their receptors. FEBS Journal, 285(16), pp. 2944-2971. (doi: 10.1111/febs.14466) (PMID:29637711) (PMCID:PMC6120486)

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The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). Consequently, chemokines play a central role in the development and homeostasis of the immune system, and are involved in all protective or destructive immune and inflammatory responses. Classically viewed as inducers of directed chemotactic migration, it is now clear that chemokines can stimulate a variety of other types of directed and undirected migratory behaviour, such as haptotaxis, chemokinesis, and haptokinesis, in addition to inducing cell arrest or adhesion. However, chemokine receptors on leukocytes can do more than just direct migration, and these molecules can also be expressed on, and regulate the biology of, many non‐leukocytic cell types. Chemokines are profoundly affected by post‐translational modification, by interaction with the extracellular matrix (ECM), and by binding to heptahelical ‘atypical’ chemokine receptors that regulate chemokine localisation and abundance. This guide gives a broad overview of the chemokine and chemokine receptor families; summarises the complex physical interactions that occur in the chemokine network; and, using specific examples, discusses general principles of chemokine function, focussing particularly on their ability to direct leukocyte migration.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Nibbs, Professor Rob and Hughes, Dr Catherine
Authors: Hughes, C. E., and Nibbs, R. J.B.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:FEBS Journal
ISSN (Online):1742-4658
Published Online:10 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in FEBS Journal 285(16): 2944-2971
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
715631Defining mechanisms that control T cell migrationSimon MillingMedical Research Council (MRC)MR/N023625/1III -IMMUNOLOGY
681091The ACKR2-CCR2 axis in development and diseaseGerard GrahamMedical Research Council (MRC)MR/M019764/1III -IMMUNOLOGY
3014990Integrative Transport Phenomena in Chemokine Gradient EstablishmentRobert NibbsWellcome Trust (WELLCOTR)206284/Z/17/ZIII - Immunology