Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62

Chaussepied, M., Moreau, M., Langsley, G., Michie, A.M. , Harnett, M. and Harnett, W. (2006) Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62. Microbes and Infection, 8(4), pp. 1189-1191. (doi: 10.1016/j.micinf.2005.11.012)

Abstract

Theileria parva-infected B cells express Jagged-1 and activate Notch signalling in a parasite-dependent manner. ES-62, a filarial nemato-desecreted phosphorylcholine-containing glycoprotein, is able to further stimulate Notch-mediated signalling in parasitized cells. Notch is also activated to a similar extent by addition of exogenous IL-10, and this occurs prior to any increase in proliferation in T. parva-infected B cells.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Michie, Professor Alison
• Authors: Chaussepied, M., Moreau, M., Langsley, G., Michie, A.M., Harnett, M., and Harnett, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Microbes and Infection
• ISSN: 1286-4579