Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3

Bailey, M. E.S. , Albrecht, B. E., Johnson, K. J. and Darlison, M. G. (1999) Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1447(2-3), pp. 307-312. (doi:10.1016/S0167-4781(99)00167-0)

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Abstract

GABAC receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but that GABRR3 maps to chromosome 3q11-q13.3. Our mapping data suggest that the ρ polypeptide genes, which are thought to share a common ancestor with GABAA receptor subunit genes, diverged at an early stage in the evolution of this gene family.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bailey, Dr Mark
Authors: Bailey, M. E.S., Albrecht, B. E., Johnson, K. J., and Darlison, M. G.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Publisher:Elsevier
ISSN:0167-4781

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