Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties

Thomson, N. C. (2018) Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties. Expert Review of Respiratory Medicine, 12(4), pp. 269-282. (doi: 10.1080/17476348.2018.1444991) (PMID:29471685)

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Introduction: Bronchial thermoplasty is a licensed non-pharmacological treatment for severe asthma. Area covered: This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. Despite some progress, future research needs to investigate uncertainties about predictors of response, mechanism of action and place in management of asthma.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Thomson, Professor Neil
Authors: Thomson, N. C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Expert Review of Respiratory Medicine
Publisher:Taylor and Francis
ISSN (Online):1747-6356
Published Online:23 February 2018
Copyright Holders:Copyright © 2018 Informa UK Limited, trading as Taylor and Francis Group
First Published:First published in Expert Review of Respiratory Medicine 12(4): 269-282
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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