Iron–sulfur clusters: from metals through mitochondria biogenesis to disease

Cardenas-Rodriguez, M., Chatzi, A. and Tokatlidis, K. (2018) Iron–sulfur clusters: from metals through mitochondria biogenesis to disease. Journal of Biological Inorganic Chemistry, 23(4), pp. 509-520. (doi: 10.1007/s00775-018-1548-6) (PMID:29511832) (PMCID:PMC6006200)

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Iron–sulfur clusters are ubiquitous inorganic co-factors that contribute to a wide range of cell pathways including the maintenance of DNA integrity, regulation of gene expression and protein translation, energy production, and antiviral response. Specifically, the iron–sulfur cluster biogenesis pathways include several proteins dedicated to the maturation of apoproteins in different cell compartments. Given the complexity of the biogenesis process itself, the iron–sulfur research area constitutes a very challenging and interesting field with still many unaddressed questions. Mutations or malfunctions affecting the iron–sulfur biogenesis machinery have been linked with an increasing amount of disorders such as Friedreich’s ataxia and various cardiomyopathies. This review aims to recap the recent discoveries both in the yeast and human iron–sulfur cluster arena, covering recent discoveries from chemistry to disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cardenas Rodriguez, Mr Mauricio and Tokatlidis, Professor Kostas and Chatzi, Ms Afroditi
Authors: Cardenas-Rodriguez, M., Chatzi, A., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Journal of Biological Inorganic Chemistry
ISSN (Online):1432-1327
Published Online:06 March 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Biological Inorganic Chemistry 23(4): 509-520
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
743461Characterizing the mitochondrial import and assembly pathway of the malaria parasitesKonstantinos TokatlidisWellcome Trust (WELLCOTR)202308/Z/16/ZRI MOLECULAR CELL & SYSTEMS BIOLOGY
624931Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.Konstantinos TokatlidisThe Royal Society (ROYSOC)WM120111RI MOLECULAR CELL & SYSTEMS BIOLOGY