Microultraound and Small Bowel Inflammation: Tissue Phantom Studies

Cox, B. F., Seetohul, V., Lay, H. and Cochran, S. (2015) Microultraound and Small Bowel Inflammation: Tissue Phantom Studies. In: 2015 IEEE International Ultrasonics Symposium, Taipei, Taiwan, 21-24 Oct 2015, ISBN 9781479981823 (doi: 10.1109/ULTSYM.2015.0304)

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Abstract

Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Seetohul, Dr Vipin and Cox, Dr Benjamin F and Cochran, Professor Sandy and Lay, Dr Holly
Authors: Cox, B. F., Seetohul, V., Lay, H., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
ISBN:9781479981823
Published Online:16 November 2015

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