Receptor control in mesenchymal stem cell engineering

Dalby, M. J. , García, A. J. and Salmeron-Sanchez, M. (2018) Receptor control in mesenchymal stem cell engineering. Nature Reviews Materials, 3, 17091. (doi: 10.1038/natrevmats.2017.91)

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Materials science offers a powerful tool to control mesenchymal stem cell (MSC) growth and differentiation into functional phenotypes. A complex interplay between the extracellular matrix and growth factors guides MSC phenotypes in vivo. In this Review, we discuss materials-based bioengineering approaches to direct MSC fate in vitro and in vivo, mimicking cell–matrix–growth factor crosstalk. We first scrutinize MSC–matrix interactions and how the properties of a material can be tailored to support MSC growth and differentiation in vitro, with an emphasis on MSC self-renewal mechanisms. We then highlight important growth factor signalling pathways and investigate various materials-based strategies for growth factor presentation and delivery. Integrin–growth factor crosstalk in the context of MSC engineering is introduced, and bioinspired material designs with the potential to control the MSC niche phenotype are considered. Finally, we summarize important milestones on the road to MSC engineering for regenerative medicine.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew
Authors: Dalby, M. J., García, A. J., and Salmeron-Sanchez, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Nature Reviews Materials
Publisher:Nature Publishing Group
ISSN (Online):2058-8437

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
653731Synergistic microenvironments for non-union bone defectsMatthew DalbyMedical Research Council (MRC)MR/L022710/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
722061Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - BIOMEDICAL ENGINEERING
717521Materials exploitation of the biointerface to control MSC quality and niche phenotypeMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N018419/1RI MOLECULAR CELL & SYSTEMS BIOLOGY