Abánades Lázaro, I., Abánades Lázaro, S. and Forgan, R. S. (2018) Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles. Chemical Communications, 54(22), pp. 2792-2795. (doi: 10.1039/C7CC09739E) (PMID:29485148)
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Abstract
Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Abanades, Isabel and Forgan, Professor Ross |
Authors: | Abánades Lázaro, I., Abánades Lázaro, S., and Forgan, R. S. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
ISSN (Online): | 1364-548X |
Published Online: | 22 February 2018 |
Copyright Holders: | Copyright © 2018 Royal Society of Chemistry |
First Published: | First published in Chemical Communications 52(22): 2792-2795 |
Publisher Policy: | Reproduced under a Creative Commons License |
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