Perochon, J. , Carroll, L. and Cordero, J. (2018) Wnt signalling in intestinal stem cells: lessons from mice and flies. Genes, 9(3), 138. (doi: 10.3390/genes9030138) (PMID:29498662) (PMCID:PMC5867859)
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Abstract
Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate. In the gastrointestinal tract, Wnt signalling activation drives homeostasis and damage-induced repair. Additionally, deregulated Wnt signalling is a common hallmark of age-associated tissue dysfunction and cancer. Studies using mouse and fruit fly models have greatly improved our understanding of the functional contribution of the Wnt signalling pathway in adult intestinal biology. Here, we summarize the latest knowledge acquired from mouse and Drosophila research regarding canonical Wnt signalling and its key functions during stem cell driven intestinal homeostasis, regeneration, ageing and cancer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Perochon, Miss Jessica and Carroll, Lynsey and Cordero, Professor Julia |
Authors: | Perochon, J., Carroll, L., and Cordero, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Genes |
Publisher: | MDPI |
ISSN: | 2073-4425 |
ISSN (Online): | 2073-4425 |
Copyright Holders: | Copyright © 2018 The Authors |
First Published: | First published in Genes 9(3):138 |
Publisher Policy: | Reproduced under a Creative Commons License |
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