Wnt signalling in intestinal stem cells: lessons from mice and flies

Perochon, J. , Carroll, L. and Cordero, J. (2018) Wnt signalling in intestinal stem cells: lessons from mice and flies. Genes, 9(3), 138. (doi: 10.3390/genes9030138) (PMID:29498662) (PMCID:PMC5867859)

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Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate. In the gastrointestinal tract, Wnt signalling activation drives homeostasis and damage-induced repair. Additionally, deregulated Wnt signalling is a common hallmark of age-associated tissue dysfunction and cancer. Studies using mouse and fruit fly models have greatly improved our understanding of the functional contribution of the Wnt signalling pathway in adult intestinal biology. Here, we summarize the latest knowledge acquired from mouse and Drosophila research regarding canonical Wnt signalling and its key functions during stem cell driven intestinal homeostasis, regeneration, ageing and cancer.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Perochon, Miss Jessica and Carroll, Lynsey and Cordero, Professor Julia
Authors: Perochon, J., Carroll, L., and Cordero, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Genes
ISSN (Online):2073-4425
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Genes 9(3):138
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
633022Regulation of stem cell function during tissue homeostasis and transformationJulia CorderoWellcome Trust (WELLCOTR)104103/Z/14/ZRI CANCER SCIENCES