Huang, J. et al. (2018) Circuit dissection of the role of somatostatin in itch and pain. Nature Neuroscience, 21(5), pp. 707-716. (doi: 10.1038/s41593-018-0119-z) (PMID:29556030) (PMCID:PMC5923877)
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157674.pdf - Accepted Version 6MB |
Abstract
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide somatostatin. We find that in the periphery, somatostatin is exclusively expressed in Nppb+ neurons, and we demonstrate that Nppb+somatostatin+ cells function as pruriceptors. Employing chemogenetics, pharmacology and cell-specific ablation methods, we demonstrate that somatostatin potentiates itch by inhibiting inhibitory dynorphin neurons, which results in disinhibition of GRPR+ neurons. Furthermore, elimination of somatostatin from primary afferents and/or from spinal interneurons demonstrates differential involvement of the peptide released from these sources in itch and pain. Our results define the neural circuit underlying somatostatin-induced itch and characterize a contrasting antinociceptive role for the peptide.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Boyle, Dr Kieran and Beresford-Polgar, Dr Erika and Todd, Professor Andrew and Riddell, Professor John and Dickie, Dr Allen |
| Authors: | Huang, J., Polgár, E., Solinski, H. J., Mishra, S. K., Tseng, P.-Y., Iwagaki, N., Boyle, K. A., Dickie, A. C., Kriegbaum, M. C., Wildner, H., Zeilhofer, H. U., Watanabe, M., Riddell, J. S., Todd, A. J., and Hoon, M. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Nature Neuroscience |
| Publisher: | Nature Publishing Group |
| ISSN: | 1097-6256 |
| ISSN (Online): | 1546-1726 |
| Published Online: | 19 March 2018 |
| Copyright Holders: | Copyright © 2018 Nature America Inc., part of Springer Nature |
| First Published: | First published in Nature Neuroscience 21(5):707-716 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
| Related URLs: |
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