Nanoimprinting of biomedical polymers reduces candidal physical adhesion

Alalwan, H., Nile, C. J. , Rajendran, R., McKerlie, R. , Reynolds, P. , Gadegaard, N. and Ramage, G. (2018) Nanoimprinting of biomedical polymers reduces candidal physical adhesion. Nanomedicine: Nanotechnology, Biology and Medicine, 14(3), pp. 1045-1049. (doi: 10.1016/j.nano.2018.01.011) (PMID:29408656)

Abstract

Management of fungal biofilms represents a significant challenge to healthcare. As a preventive approach, minimising adhesion between indwelling medical devices and microorganisms would be an important step forward. This study investigated the anti-fouling capacity of engineered nanoscale topographies to the pathogenic yeast Candida albicans. Highly ordered arrays of nano-pit topographies were shown to significantly reduce the physical adherence capacity of C. albicans. This study shows a potential of nanoscale patterns to inhibit and prevent pathogenic biofilm formation on biomedical substrates.

• Item Type: Articles
• Keywords: Candida albicans, Nanotopography, adhesion, polycarbonate, polymethyl-methacrylate.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Rajendran, Dr Ranjith and McKerlie, Mr Robert and Ramage, Professor Gordon and ALALWAN, HASANAIN KAHTAN ABDULKHALIK and Reynolds, Dr Paul and Gadegaard, Professor Nikolaj and Nile, Dr Christopher
• Authors: Alalwan, H., Nile, C. J., Rajendran, R., McKerlie, R., Reynolds, P., Gadegaard, N., and Ramage, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Nanomedicine: Nanotechnology, Biology and Medicine
• Publisher: Elsevier
• ISSN: 1549-9634
• ISSN (Online): 1549-9634
• Published Online: 02 February 2018