Cochran, S. , Button, T.W., Cox, B.F., Cumming, D.R.S. , Gourevich, D., Lay, H.S. , Mulvana, H. , Nathke, I.S. and Stewart, F. (2017) Nanotechnology in Multimodal Theranostic Capsule Endoscopy. In: IEEE 17th International Conference on Nanotechnology (IEEE-NANO), Pittsburgh, PA, USA, 25-28 July 2017, pp. 434-435. ISBN 9781509030286 (doi: 10.1109/NANO.2017.8117439)
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Abstract
Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.
| Item Type: | Conference Proceedings |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cumming, Professor David and Cochran, Professor Sandy and Lay, Dr Holly and Mulvana, Dr Helen |
| Authors: | Cochran, S., Button, T.W., Cox, B.F., Cumming, D.R.S., Gourevich, D., Lay, H.S., Mulvana, H., Nathke, I.S., and Stewart, F. |
| College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| ISBN: | 9781509030286 |
| Copyright Holders: | Copyright © 2017 IEEE |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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