Association of complement receptor 1 gene polymorphisms with cognitive function

Zijlstra, L.E., Jukema, J.W., Mooijaart, S.P., de Vries, M.A., Stott, D.J. , Castro Cabezas, M. and Trompet, S. (2018) Association of complement receptor 1 gene polymorphisms with cognitive function. Physiological Genomics, 50(2), pp. 102-103. (doi: 10.1152/physiolgenomics.00102.2017) (PMID:29212848)

Abstract

Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer’s disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 (n = 73) were assessed in 5,244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age 75.3 yr). Linear regression, adjusted for age, sex, country, and use of pravastatin, was used to assess the association between the SNPs and cognitive function. All 73 SNPs within the genomic region of the CR1 gene on chromosome 1 were extracted. Eighteen were independent, according to a relatively stringent R2 threshold of >0.8 with LDlink. Twelve of the 18 investigated CR1 SNPs were significantly associated with a decline in cognitive function (all P < 0.05). These data indicate that genetic variation within the CR1 gene is associated not only with Alzheimer’s disease, but also with general cognitive function during late life.

• Item Type: Articles
• Additional Information: The PROSPER study was supported by an investigator-initiated grant obtained from Bristol-Myers Squibb. Prof. Dr. J. W. Jukema is an Established Clinical Investigator of the Netherlands Heart Foundation (Grant 2001 D 032). Support for genotyping was provided by the seventh framework program of the European commission (Grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging Grant 050-060-810).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Stott J, Professor David
• Authors: Zijlstra, L.E., Jukema, J.W., Mooijaart, S.P., de Vries, M.A., Stott, D.J., Castro Cabezas, M., and Trompet, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Physiological Genomics
• Publisher: American Physiological Society
• ISSN: 1094-8341
• ISSN (Online): 1531-2267
• Published Online: 01 February 2018
• Copyright Holders: Copyright © 2018 the American Physiological Society
• First Published: First published in Physiological Genomics 50(2): 102-103
• Publisher Policy: Reproduced under a Creative Commons License