Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death

Parvy, J.-P., Hodgson, J. A. and Cordero, J. B. (2018) Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death. BioMed Research International, 2018, 7152962. (doi: 10.1155/2018/7152962) (PMID:29725601) (PMCID:PMC5872677)

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The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches. This is necessary in order to achieve a comprehensive understanding into the mechanisms driving disease initiation and progression, to aid the development of appropriate therapies. In recent decades, the fruit fly Drosophila melanogaster and its associated powerful genetic tools have become a very attractive model system to study tumour-intrinsic and non-tumour-derived processes that mediate tumour development in vivo. In this review, we will summarize recent work on Drosophila as a model system to study cancer biology. We will focus on the interactions between tumours and their microenvironment, including extrinsic mechanisms affecting tumour growth and how tumours impact systemic host physiology.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hodgson, Joseph Alexander and Parvy, Dr Jean-Philippe and Cordero, Professor Julia
Authors: Parvy, J.-P., Hodgson, J. A., and Cordero, J. B.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:BioMed Research International
Publisher:Hindawi Publishing Corporation
ISSN (Online):2314-6141
Copyright Holders:Copyright © 2018 Jean-Philippe Parvy et al.
First Published:First published in BioMed Research International 2018:7152962
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
633022Regulation of stem cell function during tissue homeostasis and transformationJulia CorderoWellcome Trust (WELLCOTR)104103/Z/14/ZRI CANCER SCIENCES