Ford, T. J. and Dillon, J. F. (2008) Minocycline hepatitis. European Journal of Gastroenterology and Hepatology, 20(8), pp. 796-799. (doi: 10.1097/MEG.0b013e3282f493c5) (PMID:18617786)
Full text not currently available from Enlighten.
Abstract
Minocycline is an effective antibiotic widely used in the treatment of acne vulgaris. We report a previously well 20-year-old woman who developed liver dysfunction with jaundice and malaise following a 1 year course of minocycline for acne vulgaris. Serum antinuclear antibody was strongly positive (1 : 2560) and liver transaminases were grossly deranged. All other causes of liver disease were excluded. Both the clinical symptoms and laboratory abnormalities resolved spontaneously on stopping the drug. We review the three different types of hepatotoxicity associated with minocycline and draw evidence to support the diagnosis of minocycline-induced autoimmune hepatitis. This case supports the call to monitor patients on minocycline therapy for autoimmune disease of the liver and highlights the need for a multicentre prospective trial of the risks and benefits of long-term minocycline therapy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ford, Thomas |
| Authors: | Ford, T. J., and Dillon, J. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | European Journal of Gastroenterology and Hepatology |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 0954-691X |
| ISSN (Online): | 1473-5687 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric