McDougall, L., Draper, E. R. , Beadle, J. D., Shipman, M., Raubo, P., Jamieson, A. G. and Adams, D. (2018) Enzymatically-stable oxetane-based dipeptide hydrogels. Chemical Communications, 54(14), pp. 1793-1796. (doi: 10.1039/C7CC09701H) (PMID:29384155)
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Abstract
Low molecular weight gelators that are not easily degraded by enzymes have a range of potential applications. Here, we report new Fmoc-protected dipeptides in which the amide carbonyl group has been replaced by an oxetane ring. Remarkably one of these peptidomimetics, but not the corresponding dipeptide, is an effective gelator, forming hydrogels at a concentration of 3 mg mL−1. On assembly, there is a lack of beta-sheet structure, implying that there is no requirement for this motif in such a gel. Furthermore, the modified dipeptide is also stable to proteolysis compared to the parent dipeptide.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Draper, Emily and Adams, Dave and Jamieson, Professor Andrew and Shipman, Mr Michael and McDougall, Miss Laura |
Authors: | McDougall, L., Draper, E. R., Beadle, J. D., Shipman, M., Raubo, P., Jamieson, A. G., and Adams, D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
ISSN (Online): | 1364-548X |
Published Online: | 24 January 2018 |
Copyright Holders: | Copyright © 2018 The Royal Society of Chemistry |
First Published: | First published in Chemical Communications 54(14): 1793-1796 |
Publisher Policy: | Reproduced under a Creative Commons License |
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