Cooper, S.-A. , Smiley, E., Allan, L. and Morrison, J. (2018) Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study. British Journal of Psychiatry, 212(5), pp. 295-300. (doi: 10.1192/bjp.2018.12) (PMID:29540250)
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Abstract
Background: Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown. Aims: To investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports. Method: Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years. Results: There was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression. Conclusions: Depression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Smiley, Dr Elita and Cooper, Professor Sally-Ann and Allan, Mrs Linda and Morrison, Professor Jill |
Authors: | Cooper, S.-A., Smiley, E., Allan, L., and Morrison, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | British Journal of Psychiatry |
Publisher: | Royal College of Psychiatrists |
ISSN: | 0007-1250 |
ISSN (Online): | 1472-1465 |
Published Online: | 15 March 2018 |
Copyright Holders: | Copyright © 2018 The Royal College of Psychiatrists |
First Published: | First published in British Journal of Psychiatry 212(5):295-300 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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