Chen, Y., Haveman, J. W., Apostolou, C., Chang, D. K. and Merrett, N. D. (2015) Asian gastric cancer patients show superior survival: the experiences of a single Australian center. Gastric Cancer, 18(2), pp. 256-261. (doi: 10.1007/s10120-014-0383-x) (PMID:24858392)
Full text not currently available from Enlighten.
Abstract
Background: Survival after curative gastrectomy for gastric cancer varies depending on region. The 5-year survival rates in Western trials reach 36–47 % compared with 40–60 % in Japanese studies. We analyzed the outcomes of Asian and non-Asian patients at a single Australian institution. Methods: We analyzed a prospectively kept database of patients following gastric resection between 1994 and 2010 at a tertiary Australian hospital. Overall survival was the primary endpoint. Results: A total of 160 patients underwent a R0 gastrectomy with curative intent, of whom 26 (16 %) were of Asian descent. Asian patients had a significantly younger age at diagnosis (60 ± 16 vs. 70 ± 11, p < 0.05) and longer overall survival (log-rank p = 0.018). Poor prognostic factors common to both groups included increased tumor length, higher T-score, higher LN ratio, poor tumor differentiation, and the presence of perineural or perivascular invasion. Multivariate analysis showed that non-Asian patients, higher T-score, higher N-score, and perivascular involvement were all independent predictors of poorer outcome. Conclusions: This study shows superior overall survival in Asian patients despite similar clinicopathological and treatment data. The younger age at diagnosis in Asian patients may suggest a different disease process between ethnicities. Targeted therapies based on population-specific tumor biology may potentially be beneficial.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Chang, Professor David |
| Authors: | Chen, Y., Haveman, J. W., Apostolou, C., Chang, D. K., and Merrett, N. D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Gastric Cancer |
| Publisher: | Springer |
| ISSN: | 1436-3291 |
| ISSN (Online): | 1436-3305 |
| Published Online: | 25 May 2014 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric