Improving outcomes for operable pancreatic cancer: Is access to safer surgery the problem?

Chang, D. K. , Merrett, N. D. and Biankin, A. V. (2008) Improving outcomes for operable pancreatic cancer: Is access to safer surgery the problem? Journal of Gastroenterology and Hepatology, 23(7pt1), pp. 1036-1045. (doi: 10.1111/j.1440-1746.2008.05471.x) (PMID:18707598)

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Despite advances in the understanding and treatment of pancreatic cancer in the last two decades, there is a persisting nihilistic attitude among clinicians. An alarmingly high rate of under-utilization of surgical management for operable pancreatic cancer was recently reported in the USA, where more than half of patients with stage 1 operable disease and no other contraindications were not offered surgery as therapy, denying this group of patients a 20% chance of long-term survival. These data indicate that a nihilistic attitude among clinicians may be a significant and reversible cause of the persisting high mortality of patients with pancreatic cancer. This article examines the modern management of pancreatic cancer, in particular, the advances in surgical care that have reduced the mortality of pancreatectomy to almost that of colonic resection, and outlines a strategy for improving outcomes for patients with pancreatic cancer now and in the future.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Biankin, Professor Andrew and Chang, Professor David
Authors: Chang, D. K., Merrett, N. D., and Biankin, A. V.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Journal of Gastroenterology and Hepatology
Publisher:Wiley-Blackwell Publishing
ISSN (Online):1440-1746
Published Online:16 July 2008

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