Retrograde signaling from autophagy modulates stress responses

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi: 10.1126/scisignal.aag2791) (PMID:28246201)

155491.pdf - Accepted Version



Macroautophagy is a process in which cytoplasmic components, including whole organelles, are degraded within lysosomes. Basally, this process is essential for homeostasis and is constitutively functional in most cells, but it can also be implemented as part of stress responses. We discuss findings showing that autophagy proteins can modulate and amplify the activities of transcription factors involved in stress responses, such as those in the p53, FOXO, MiT/TFE, Nrf2, and NFκB/Rel families. Thus, transcription factors not only amplify stress responses and autophagy but are also subject to retrograde regulation by autophagy-related proteins. Physical interactions with autophagy-related proteins, competition for activating intermediates, and “signalphagy,” which is the role autophagy plays in the degradation of specific signaling proteins, together provide powerful tools for implementing negative feedback or positive feed-forward loops on the transcription factors that regulate autophagy. We present examples illustrating how this network interacts to regulate metabolic and physiologic responses.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tait, Professor Stephen and Ryan, Professor Kevin
Authors: Simon, H.-U., Friis, R., Tait, S. W.G., and Ryan, K. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Science Signaling
Publisher:American Association for the Advancement of Science (AAAS)
ISSN (Online):1937-9145
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Science Signaling 10(468): eaag2791
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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