Cong, W.-j. , Liu, Q.-f., Liang, Q.-l., Luo, G.-a., Ruan, K.-f. and Feng, Y. (2012) Serum metabolites of commerical pirarubicin injections. Chinese Pharmacological Bulletin, 2012(9), (doi: 10.3969/j.issn.1001-1978.2012.09.025)
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Abstract
Aim: To investigate the cumulative toxicity of commercial pirarubicin injection after 2 intravenous administrations on the normal sprague-dawley rats with serum metabonomics. Methods: The metabolic profiles of serum sample were obtained with ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC/TOF-MS). The data were further processed with Masslynx software and analyzed with partial least squares discriminate analysis (PLS-DA). On the basis of a VIP (variable importance in projection) threshold of 1 from the 7-fold cross-validated PLS-DA model and student's test, potential biomarkers responsible for the difference in the metabolic profiles were obtained. Finally, they were identified by authentic standards or available databases. Results: It could be found that multiple dosages of THP would lead to fatty acids and phospholipids disturbance and severe cardiotoxicity via adriamycinone through the reactive oxygen species (ROS) mechanism. Conclusion: This study can provide a basis for the potential biomarkers screening of the cumulative cardiotoxicity of commercial pirarubicin injection in clinic.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cong, Dr Wenjuan |
| Authors: | Cong, W.-j., Liu, Q.-f., Liang, Q.-l., Luo, G.-a., Ruan, K.-f., and Feng, Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Chinese Pharmacological Bulletin |
| Publisher: | Zhongguo Yaoli Xuehui |
| ISSN: | 1001-1978 |
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