Wang, B., Shen, L., Cong, W.-j. , Zhu, Y.-Y., Wang, Q. and Feng, Y. (2013) Serum metabonomic study on liuwei dihuang pills in the treatment of hyperthyroidism. Chinese Pharmacological Bulletin, 2013(05), (doi: 10.3969/j.issn.1001-1978.2013.05.010)
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Abstract
Aim: To explore the underlying mechanism of hyperthyroidism induced by subcutaneous injection of L-levothyroxine sodium and and intervention effects of Liuwei Dihuang pills on sprague dawley rats via serum metabolomics. Methods: After rats were injected with L-levothyroxine sodium at a dosage of 35 μg·(100 g)-1 every day for 1 week,and then Liuwei dihuang pills(LDPs) were treated at a dose of 4.7 g·kg-1 for 3 consecutive weeks.The serum samples for rats were obtained after the treatment of LDPS and the metabolic profiles of serum were obtained with ultra performance liquid chromatography coupled with time-of-flight mass spectrometry(UPLC-QTOF-MS). Results: The levels of oxaloacetic acid,Dihydroxyacetone phosphate(DHAP),ethyl glucuronide,triglyceride,lysophospholipids and cholesterol were significantly increased in the model group as compared to the normal rats.Moreover,these levels could be regulated to be close to normal after the treatment of LDPS. Conclusions: There is severe disturbance in the tricarboxylic acid cycle as well as sugar and lipid metabolism for hyperthyroidism rats.LDPS can exhibite obvious effects on the treatment of hyperthyroidism.Serum metabonomics analysis reveals the changes of metabolites traits during the treatment of LDPS,thus providing a supplementary evaluation method of LDPS in the treatment of hyperthyroidism.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cong, Dr Wenjuan |
| Authors: | Wang, B., Shen, L., Cong, W.-j., Zhu, Y.-Y., Wang, Q., and Feng, Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Chinese Pharmacological Bulletin |
| Publisher: | Zhongguo Yaoli Xuehui |
| ISSN: | 1001-1978 |
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