Meurs, K.M., Stern, J.A., Reina-Doreste, Y., Spier, A.W., Koplitz, S.L. and Baumwart, R.D. (2014) Natural history of arrhythmogenic right ventricular cardiomyopathy in the boxer dog: a prospective study. Journal of Veterinary Internal Medicine, 28(4), pp. 1214-1220. (doi: 10.1111/jvim.12385) (PMID:24962663) (PMCID:PMC4857953)
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Abstract
Background: Boxer arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease that may result in sudden death or heart failure. Hypothesis/objectives: To prospectively study the natural history of Boxer ARVC. Animals: 72 dogs (49 ARVC, 23 controls). Methods: Boxers >1 year of age were recruited for annual reevaluation. Controls were defined as being ≥6 years of age and having <50 ventricular premature complex (VPCs)/24 h. ARVC was defined as ≥300 VPCs/24 h in the absence of other disease. Dogs were genotyped for the striatin deletion when possible. Descriptive statistics were determined for age; VPC number; annual change in VPC number; and left ventricular (LV) echocardiographic dimensions. Survival time was calculated. Results: Controls: median age of 7 years (range, 6–10); number of VPCs 12 (range, 4–32). Median time in study of 6 years (range, 2–9). Seventeen of 23 were genotyped (5 positive, 12 negative). ARVC: median age of diagnosis of 6 (range, 1–11). Median time in study 5 years (range, 3–8). A total of 33% were syncopal and 43/49 were genotyped (36 positive, 7 negative). Yearly change in VPCs was 46 (range, −7,699 to 33,524). Annual percentage change in LV dimensions was 0, and change in fractional shortening (FS%) was 2%. Two dogs had FS% <20%. Although ARVC dogs died suddenly, there was no difference in survival time between groups. ARVC median age of survival was 11 years, and for controls was 10 years. Conclusions/Clinical Importance: Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion. Syncope occurs in approximately 1/3 of affected dogs; systolic dysfunction is uncommon. The prognosis in many affected dogs is good.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Reina Doreste, Mr Yamir |
| Authors: | Meurs, K.M., Stern, J.A., Reina-Doreste, Y., Spier, A.W., Koplitz, S.L., and Baumwart, R.D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Veterinary Internal Medicine |
| Publisher: | American College of Veterinary Internal Medicine. |
| ISSN: | 0891-6640 |
| ISSN (Online): | 1939-1676 |
| Published Online: | 24 June 2014 |
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