Development of a Therapeutic Capsule Endoscope for Treatment in the Gastrointestinal Tract: Bench Testing to Translational Trial

Stewart, F. R., Newton, I. P., Nathke, I., Huang, Z., Cox, B. F. and Cochran, S. (2017) Development of a Therapeutic Capsule Endoscope for Treatment in the Gastrointestinal Tract: Bench Testing to Translational Trial. In: 2017 IEEE International Ultrasonics Symposium (IUS), Washington, D.C., USA, 6-9 Sept 2017, ISBN 9781538633830 (doi:10.1109/ULTSYM.2017.8091791)

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Abstract

Video capsule endoscopy is a widely accepted clinical alternative to conventional endoscopy for examination of the gastrointestinal tract. Its advantages are that it can visualize the entire gastrointestinal tract including the anatomically remote small intestine and it is less invasive for the patient as compared to conventional endoscopy. However, video capsule endoscopy is suitable only for diagnosis, with little research into therapeutic capsule endoscopy. Like video capsule endoscopy, therapeutic capsule endoscopy has great potential to reach locations that would previously have been difficult, such as the small intestine. Ultrasound-mediated targeted drug delivery is a promising therapeutic capsule based modality as it may be scaled to size, provides temporary gut barrier disruption and power requirement is relatively low. This paper investigates the feasibility of a therapeutic capsule endoscope utilizing ultrasound-mediated targeted drug delivery. A prototype device, SonoCAIT, was built and tested. Further investigation of the drug delivery capabilities of the miniature focused US sources, testing was carried out on an in vitro model replicating the lining of the small intestine. This involved measuring the transepithelial resistance, a measure for barrier function, during insonation. A drop in transepithelial resistance occurred during insonation and returned to starting value post insonation. In anticipation of in vivo work, SonoCAIT, was reconfigured to operate within the small bowel of pigs.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cochran, Professor Sandy
Authors: Stewart, F. R., Newton, I. P., Nathke, I., Huang, Z., Cox, B. F., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
ISSN:1948-5727
ISBN:9781538633830
Published Online:02 November 2017
Copyright Holders:Copyright © 2017 IEEE
First Published:First published in 2017 IEEE International Ultrasonics Symposium (IUS)
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG