The spread and evolution of rabies virus: conquering new frontiers

Fisher, C. R., Streicker, D. G. and Schnell, M. J. (2018) The spread and evolution of rabies virus: conquering new frontiers. Nature Reviews Microbiology, 16, pp. 241-255. (doi: 10.1038/nrmicro.2018.11) (PMID:29479072) (PMCID:PMC6899062)

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Rabies is a lethal zoonotic disease that is caused by lyssaviruses, most often rabies virus. Despite control efforts, sporadic outbreaks in wildlife populations are largely unpredictable, underscoring our incomplete knowledge of what governs viral transmission and spread in reservoir hosts. Furthermore, the evolutionary history of rabies virus and related lyssaviruses remains largely unclear. Robust surveillance efforts combined with diagnostics and disease modelling are now providing insights into the epidemiology and evolution of rabies virus. The immune status of the host, the nature of exposure and strain differences all clearly influence infection and transmission dynamics. In this Review, we focus on rabies virus infections in the wildlife and synthesize current knowledge in the rapidly advancing fields of rabies virus epidemiology and evolution, and advocate for multidisciplinary approaches to advance our understanding of this disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Streicker, Professor Daniel
Authors: Fisher, C. R., Streicker, D. G., and Schnell, M. J.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Nature Reviews Microbiology
Publisher:Nature Publishing Group
ISSN (Online):1740-1534
Published Online:26 February 2018
Copyright Holders:Copyright © 2018 Macmillan Publishers Limited
First Published:First published in Nature Reviews Microbiology 16:241-255
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
634192Managing viral emergence at the interface of bats and livestockDaniel StreickerWellcome Trust (WELLCOTR)102507/Z/13/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED