Exploring stem cell heterogeneity in chronic myeloid leukemia

Munje, C. and Copland, M. (2018) Exploring stem cell heterogeneity in chronic myeloid leukemia. Trends in Cancer, 4(3), pp. 167-169. (doi:10.1016/j.trecan.2017.12.001) (PMID:29506666)

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Abstract

Until very recently, understanding the complexity of the stem cell (SC) compartment in both normal and leukemic hematopoiesis has been challenging due to the inability to separate and study normal and leukemic SCs at the single-cell level. Recent advances in cell-sorting techniques and single-cell technologies now make this possible, with the identification of a population of highly quiescent chronic myeloid leukemia (CML) SCs that is enriched following therapy with tyrosine kinase inhibitors (TKIs).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Munje, Dr Chinmay and Copland, Professor Mhairi
Authors: Munje, C., and Copland, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Cancer
Publisher:Elsevier
ISSN:2405-8033
ISSN (Online):2405-8033
Published Online:21 December 2017
Copyright Holders:Copyright © 2017 Elsevier
First Published:First published in Trends in Cancer 4(3):167-169
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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