Biocatalytically triggered co-assembly of two-component core/shell nanofibers

Abul-Haija, Y. M. , Roy, S., Frederix, P. W. J. M., Javid, N., Jayawarna, V. and Ulijn, R. V. (2014) Biocatalytically triggered co-assembly of two-component core/shell nanofibers. Small, 10(5), pp. 973-979. (doi:10.1002/smll.201301668) (PMID:24027125)

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Abstract

For the development of applications and novel uses for peptide nanostructures, robust routes for their surface functionalization, that ideally do not interfere with their self-assembly properties, are required. Many existing methods rely on covalent functionalization, where building blocks are appended with functional groups, either pre- or post-assembly. A facile supramolecular approach is demonstrated for the formation of functionalized nanofibers by combining the advantages of biocatalytic self-assembly and surfactant/gelator co-assembly. This is achieved by enzymatically triggered reconfiguration of free flowing micellar aggregates of pre-gelators and functional surfactants to form nanofibers that incorporate and display the surfactants’ functionality at the surface. Furthermore, by varying enzyme concentration, the gel stiffness and supramolecular organization of building blocks can be varied.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abul-Haija, Yousef and Jayawarna, Dr Vineetha
Authors: Abul-Haija, Y. M., Roy, S., Frederix, P. W. J. M., Javid, N., Jayawarna, V., and Ulijn, R. V.
College/School:College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Small
Publisher:Wiley
ISSN:1613-6810
ISSN (Online):1613-6829
Published Online:11 September 2013

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