Abul-Haija, Y. M. and Ulijn, R. V. (2014) Enzyme-responsive hydrogels for biomedical applications. In: Connon, C. J. and Hamley, I. W. (eds.) Hydrogels in Cell-Based Therapies. Series: RSC soft matter series. Royal Society of Chemistry: Cambridge, pp. 112-134. ISBN 9781849737982 (doi: 10.1039/9781782622055-00112)
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Publisher's URL: http://pubs.rsc.org/en/content/ebook/978-1-84973-798-2
Abstract
This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.
| Item Type: | Book Sections |
|---|---|
| Status: | Published |
| Glasgow Author(s) Enlighten ID: | Abul-Haija, Yousef |
| Authors: | Abul-Haija, Y. M., and Ulijn, R. V. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2048-769X |
| ISBN: | 9781849737982 |
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