New pharmacological approaches in heart failure therapy: developments and possibilities

Cuthbert, J. J., Pellicori, P. , Shah, P. and Clark, A. L. (2017) New pharmacological approaches in heart failure therapy: developments and possibilities. Future Cardiology, 13(2), pp. 173-188. (doi: 10.2217/fca-2016-0068) (PMID:28181443)

Abstract

There have been few major breakthroughs in heart failure (HF) drug therapies in recent years yet HF morbidity and mortality remain high, and there is a clear need for further research. Several newer agents that appear promising in Phase I and II trials do not progress to show clinical benefit in later trials. Part of the failure to find new therapies may lie in flawed trial design compounded by the need for ever-increasing patient numbers in order to prove outcome benefit. We summarize some of the most recent and promising medical therapies for HF.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Pellicori, Dr Pierpaolo
• Authors: Cuthbert, J. J., Pellicori, P., Shah, P., and Clark, A. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
• Journal Name: Future Cardiology
• Publisher: Future Medicine
• ISSN: 1479-6678
• ISSN (Online): 1744-8298
• Published Online: 09 February 2017