Pharmacological and non-pharmacological treatment for decompensated heart failure: what is new?

Shah, P., Pellicori, P. , Cuthbert, J. and Clark, A. L. (2017) Pharmacological and non-pharmacological treatment for decompensated heart failure: what is new? Current Heart Failure Reports, 14(3), pp. 147-157. (doi: 10.1007/s11897-017-0328-x) (PMID:28421408) (PMCID:PMC5423987)

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Abstract

Purpose of the Review: Acute heart failure (AHF) is a life-threatening clinical condition that requires prompt medical attention. The aim of the current review is to summarise the results of recent clinical trials conducted in patients with AHF. Recent Findings: Several novel compounds have apparently beneficial acute effects on cardiovascular haemodynamics and patients’ symptoms, but their administration has not yet translated into improved survival and has been deleterious in some cases. Summary: The management of patients with AHF is challenging and reflects the heterogeneity of patient’s presentation, the complexity and severity of a multi-organ syndrome, and the limited therapeutic options, usually restricted to a combination of diuretics and vasodilators. Ongoing trials of novel treatments may provide evidence of an effect on outcomes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pellicori, Dr Pierpaolo
Authors: Shah, P., Pellicori, P., Cuthbert, J., and Clark, A. L.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
Journal Name:Current Heart Failure Reports
Publisher:Springer
ISSN:1546-9530
ISSN (Online):1546-9549
Published Online:18 April 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Current Heart Failure Reports 14(3):147-157
Publisher Policy:Reproduced under a Creative Commons License

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