Neutrophils: homing in on the myeloid mechanisms of metastasis

Leach, J., Morton, J. P. and Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi: 10.1016/j.molimm.2017.12.013) (PMID:29269005) (PMCID:PMC6544568)

Abstract

The metastasis cascade is complex and comprises several stages including local invasion into surrounding tissue, intravasation and survival of tumour cells in the circulation, and extravasation and colonisation of a distant site. It is increasingly clear that these processes are driven not only by signals within the tumour cells, but are also profoundly influenced by stromal cells and signals in the tumour microenvironment. Amongst the many cell types within the tumour microenvironment, immune cells such as lymphocytes, macrophages and neutrophils play a prominent role in tumour development and progression. Neutrophils, however, have only recently emerged as important players, particularly in metastasis. Here we review the current evidence suggesting a multi-faceted role for neutrophils in the metastatic cascade.

• Item Type: Articles
• Additional Information: This work was supported by Cancer Research UK. JL is funded by an MRC Clinical Research Training Fellowship.
• Keywords: Epithelial cancer, metastasis, myeloid cells, neutrophils, tumour microenvironment.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Leach, Dr Joshua and Morton, Professor Jen and Sansom, Professor Owen
• Authors: Leach, J., Morton, J. P., and Sansom, O. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Molecular Immunology
• Publisher: Elsevier
• ISSN: 0161-5890
• ISSN (Online): 1872-9142
• Published Online: 18 December 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Molecular Immunology 110: 69-76
• Publisher Policy: Reproduced under a Creative Commons License