de Beauchamp, L., Baquero, P., Kuntz, E. M., Gottlieb, E. and Helgason, G. V. (2018) Auto-commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”. Molecular and Cellular Oncology, 5(1), e1403532. (doi: 10.1080/23723556.2017.1403532) (PMID:28920959) (PMCID:PMC5657469)
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154375.pdf - Accepted Version 859kB |
Abstract
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kuntz, Elodie Marie and Helgason, Professor Vignir and Gottlieb, Professor Eyal and Baquero, Dr Pablo |
| Authors: | de Beauchamp, L., Baquero, P., Kuntz, E. M., Gottlieb, E., and Helgason, G. V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Molecular and Cellular Oncology |
| Publisher: | Taylor and Francis |
| ISSN: | 2372-3556 |
| ISSN (Online): | 2372-3548 |
| Published Online: | 27 November 2017 |
| Copyright Holders: | Error parsing XML in render_xhtml_field: :1: parser error : xmlParseEntityRef: no name
<fragment>Copyright © 2018 Taylor & Francis Group, LLC</fragment>
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| First Published: | First published in Molecular and Cellular Oncology 5(1):e1403532 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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