Advances in the management of rheumatoid arthritis

Dale, J. (2015) Advances in the management of rheumatoid arthritis. Scottish Medical Journal, 60(3), pp. 108-114. (doi: 10.1177/0036933015592761) (PMID:26122283)

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Modern early rheumatoid arthritis strategies are usually based upon a number of important overarching principles: 1. early diagnosis facilitates early commencement of disease modifying anti-rheumatic therapy; 2. early commencement of treatment reduces the long-term risk of erosive damage and functional decline; 3. composite disease activity measures should be used to quantify global rheumatoid arthritis disease activity; and 4. therapy should be intensified until a predefined disease activity target has been achieved. A substantial minority of rheumatoid arthritis patients (approximately 40%) will experience an adequate response to methotrexate monotherapy; however, the remainder may require disease modifying anti-rheumatic combination therapy, and/or biologic therapy, to achieve disease activity targets. Importantly, short term trials of methotrexate monotherapy do not appear to disadvantage outcomes provided treatment continues to be intensified if disease activity targets are not achieved.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dale, Dr James
Authors: Dale, J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Scottish Medical Journal
Publisher:SAGE Publications
ISSN (Online):02045-6441
Published Online:29 June 2015

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