Urinary peptidomics in kidney disease and drug research

Krochmal, M., Schanstra, J. P. and Mischak, H. (2018) Urinary peptidomics in kidney disease and drug research. Expert Opinion on Drug Discovery, 13(3), pp. 259-268. (doi: 10.1080/17460441.2018.1418320) (PMID:29240457)

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Introduction: Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases. The authors provide an overview of current achievements and potential future applications. Expert opinion: The urinary peptidome is a dynamically changing source of information, able to reflect sudden and long-term changes affecting the renal system. Studies utilizing urinary peptidomics techniques have demonstrated their value in patient stratification and detection of early pathological changes in kidney disease. Serving as a liquid biopsy, urinary peptides are an invaluable tool for drug response monitoring. Nevertheless, peptidomics is largely underexplored in drug research in general, as evidenced by the scarce number of scientific publications on this topic. Further progress will be driven by the successful validation of current discoveries and continued efforts to improve the translation of results into therapeutic applications.

Item Type:Articles
Keywords:Biomarker, clinical proteomics, drug discovery, kidney disease, peptidomics, urine.
Glasgow Author(s) Enlighten ID:Mischak, Professor Harald
Authors: Krochmal, M., Schanstra, J. P., and Mischak, H.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Expert Opinion on Drug Discovery
Publisher:Taylor and Francis
ISSN (Online):1746-045X
Published Online:14 December 2017

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
637441IMODE-CKD: Clinical and system-omics for the identification of the Molecular Determinants of established Chronic Kidney DiseaseHolger HusiEuropean Commission (EC)608332RI CARDIOVASCULAR & MEDICAL SCIENCES
593511SysVascChristian DellesEuropean Commission (EC)603288RI CARDIOVASCULAR & MEDICAL SCIENCES