Pease, R.J. and Leiper, J.M. (1996) Regulation of hepatic apolipoprotein-B-containing lipoprotein secretion. Current Opinion in Lipidology, 7(3), pp. 132-138. (PMID:8818509)
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Abstract
The overall secretion of hepatic lipid as VLDL may be regulated by (i) changing the number of particles secreted as a result of altering apolipoprotein B output and (ii) changing the degree of lipidation of the particles with triacylglycerol so that their diameters vary over a threefold range. Substantial progress has been made in understanding the pathway of triacylglycerol incorporation into VLDL. Less is understood about the processes that commit apolipoprotein B either to secretion or to presecretory degradation, although both regulated translocation and an early lipidation step of the nascent particle with cholesterol or cholesterol ester have been implicated.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Leiper, Professor James |
| Authors: | Pease, R.J., and Leiper, J.M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Current Opinion in Lipidology |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 0957-9672 |
| ISSN (Online): | 1473-6535 |
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