Long-term skeletal disproportion in childhood-onset Crohn’s disease

Mason, A., Gerasimidis, K. , Iljuhhina, J., Laird, S., Munro, J., Gaya, D. R., Russell, R. K. and Ahmed, S. F. (2018) Long-term skeletal disproportion in childhood-onset Crohn’s disease. Hormone Research in Paediatrics, 89(2), pp. 132-135. (doi: 10.1159/000485185)

Abstract

Background: It is unclear whether Crohn’s disease (CD) is associated with skeletal disproportion in adulthood. Methods: Height (Ht), sitting height (SHt) and leg length were studied in 44 children (male: 22), 23 adults (male: 10) with childhood-onset (CO) CD and 26 adults (male: 9) with adult-onset (AO) CD with a median (range) age of 13.7 (10, 17.3), 21.5 (18, 32) and 31.0 (22, 40) years, respectively. Results: Adults with CO-CD had a median Ht standard deviation score (SDS) of –0.9 (–2.3, 0.0) compared to 0.6 (–0.8, 1.0) in those with AO-CD (p < 0.05). Compared to a normal population, men, but not women, with CO-CD also had lower median SHt SDS at –1.1 (2.5, –0.5) (p < 0.05). The expected positive association that is normally found between leg length and SHt SDS was not evident in the adults with CO-CD. Conclusion: Short stature in adults with CO-CD is more pronounced in men and may be associated with poor spinal growth.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Russell, Dr Richard and Gaya, Mr Daniel and Mason, Dr Avril and Ahmed, Professor Syed Faisal and Gerasimidis, Professor Konstantinos
• Authors: Mason, A., Gerasimidis, K., Iljuhhina, J., Laird, S., Munro, J., Gaya, D. R., Russell, R. K., and Ahmed, S. F.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Hormone Research in Paediatrics
• Publisher: Karger Publishers
• ISSN: 1663-2818
• ISSN (Online): 1663-2826
• Published Online: 06 December 2017
• Copyright Holders: Copyright © 2017 S. Karger AG
• First Published: First published in Hormone Research in Paediatrics 89(2):132-135
• Publisher Policy: Reproduced in accordance with the publisher copyright policy