Mikanmaa, E., Grent-'t-Jong, T. , Hua, L., Recasens, M., Thune, H. and Uhlhaas, P. J. (2019) Towards a neurodynamical understanding of the prodrome in schizophrenia. NeuroImage, 190, pp. 144-153. (doi: 10.1016/j.neuroimage.2017.11.026) (PMID:29175199)
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Abstract
The identification of biomarkers for the early diagnosis of schizophrenia that could inform novel treatment developments is an important objective of current research. This paper will summarize recent work that has investigated changes in oscillatory activity and event-related potentials with Electro/Magnetoencephalography (EEG/MEG) in participants at high-risk for the development of schizophrenia, highlighting disruptions in sensory and cognitive operations prior to the onset of the syndrome. Changes in EEG/MEG-data are consistent with evidence for alterations in Glutamatergic and GABAergic neurotransmission as disclosed by Magnetic Resonance Spectroscopy and brain stimulation, indicating changes in Excitation/Inhibition Parameters prior to the onset of psychosis. Together these data emphasize the importance of research into neuronal dynamics as a crucial approach to establish functional relationships between impairments in neural circuits and emerging psychopathology that together could be fundamental for early intervention and the identification of novel treatments for emerging psychosis.
Item Type: | Articles |
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Keywords: | E/I-balance, electrophysiology, neuroscience, oscillations, prodrome, schizophrenia. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Uhlhaas, Professor Peter and Recasens, Dr Marc and Mikanmaa, Miss Emmi and Grent-'T-Jong, Dr Tineke and Hua, Lingling |
Authors: | Mikanmaa, E., Grent-'t-Jong, T., Hua, L., Recasens, M., Thune, H., and Uhlhaas, P. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience College of Science and Engineering > School of Psychology |
Journal Name: | NeuroImage |
Publisher: | Elsevier |
ISSN: | 1053-8119 |
ISSN (Online): | 1095-9572 |
Published Online: | 22 November 2017 |
Copyright Holders: | Copyright © 2017 Elsevier Inc. |
First Published: | First published in NeuroImage 190: 144-153 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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