Pages, B. J., Sakoff, J., Gilbert, J., Zhang, Y., Kelly, S. M. , Hoeschele, J. D. and Aldrich-Wright, J. R. (2018) Combining the platinum(ii) drug candidate kiteplatin with 1,10-phenanthroline analogues. Dalton Transactions, 47(7), pp. 2101-2472. (doi: 10.1039/c7dt04108j) (PMID:29192713)
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Abstract
Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy, elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNA binding affinity of these complexes was determined by isothermal titration calorimetry, revealing higher DNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.
Item Type: | Articles |
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Additional Information: | We thank Western Sydney University for providing financial support through internal research grants. B. J. P. was supported by an Australian Postgraduate Award and a Western Sydney University Top-Up Award. |
Keywords: | Inorganic chemistry. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kelly, Dr Sharon |
Authors: | Pages, B. J., Sakoff, J., Gilbert, J., Zhang, Y., Kelly, S. M., Hoeschele, J. D., and Aldrich-Wright, J. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Dalton Transactions |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-9226 |
ISSN (Online): | 1477-9234 |
Published Online: | 27 November 2017 |
Copyright Holders: | Copyright © 2018 The Royal Society of Chemistry |
First Published: | First published in Dalton Transactions 47(7):2101-2472 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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