Kaspersen, M. H., Jenkins, L. , Dunlop, J. , Milligan, G. and Ulven, T. (2017) Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. MedChemComm, 8(6), pp. 1360-1365. (doi: 10.1039/c7md00130d)
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Abstract
Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.
| Item Type: | Articles |
|---|---|
| Keywords: | Biochemistry, pharmaceutical science. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jenkins, Mrs Laura and Dunlop, Mrs Julia and Milligan, Professor Graeme |
| Authors: | Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G., and Ulven, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | MedChemComm |
| Publisher: | Royal Society of Chemistry (RSC) |
| ISSN: | 2040-2503 |
| ISSN (Online): | 2040-2511 |
| Published Online: | 12 May 2017 |
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