Convergent evolution of gene networks by single-gene duplications in higher eukaryotes

Amoutzias, G. D., Robertson, D. L. , Oliver, S. G. and Bornberg-Bauer, E. (2004) Convergent evolution of gene networks by single-gene duplications in higher eukaryotes. EMBO Reports, 5(3), pp. 274-279. (doi: 10.1038/sj.embor.7400096) (PMID:14968135) (PMCID:PMC1299007)

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By combining phylogenetic, proteomic and structural information, we have elucidated the evolutionary driving forces for the gene-regulatory interaction networks of basic helix-loop-helix transcription factors. We infer that recurrent events of single-gene duplication and domain rearrangement repeatedly gave rise to distinct networks with almost identical hub-based topologies, and multiple activators and repressors. We thus provide the first empirical evidence for scale-free protein networks emerging through single-gene duplications, the dominant importance of molecular modularity in the bottom-up construction of complex biological entities, and the convergent evolution of networks.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Robertson, Professor David
Authors: Amoutzias, G. D., Robertson, D. L., Oliver, S. G., and Bornberg-Bauer, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:EMBO Reports
Publisher:EMBO Press
ISSN (Online):1469-3178
Published Online:13 February 2004

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