Huxley-Jones, J., Robertson, D. L. and Boot-Handford, R. P. (2007) On the origins of the extracellular matrix in vertebrates. Matrix Biology, 26(1), pp. 2-11. (doi: 10.1016/j.matbio.2006.09.008) (PMID:17055232)
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Abstract
Extracellular matrix (ECM) is a key metazoan characteristic. In addition to providing structure and orientation to tissues, it is involved in many cellular processes such as adhesion, migration, proliferation and differentiation. Here we provide a comprehensive analysis of ECM molecules focussing on when vertebrate specific matrices evolved. We identify 60 ECM genes and 20 associated processing enzymes in the genome of the urochordate Ciona intestinalis. A comparison with vertebrate and protostome genomes has permitted the identification of both a core set of metazoan matrix genes and vertebrate-specific innovations in the ECM. We have identified a few potential cases of de novo vertebrate ECM gene innovation, but the majority of ECM genes have resulted from duplication of pre-existing genes present in the ancestral vertebrate. In conclusion, the modern complexity we see in vertebrate ECM has come about largely by duplication and modification of pre-existing matrix molecules. Extracellular matrix genes and their processing enzymes appear to be over-represented in the vertebrate genome suggesting that these genes played an active role enabling and underpinning the evolution of vertebrates.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Robertson, Professor David |
Authors: | Huxley-Jones, J., Robertson, D. L., and Boot-Handford, R. P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Matrix Biology |
Publisher: | Elsevier |
ISSN: | 0945-053X |
ISSN (Online): | 1569-1802 |
Published Online: | 19 September 2006 |
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