Protein interactions from complexes: a structural perspective

Hakes, L., Robertson, D. L. , Oliver, S. G. and Lovell, S. C. (2007) Protein interactions from complexes: a structural perspective. Comparative and Functional Genomics, 2007, 49356. (doi:10.1155/2007/49356) (PMID:17538689) (PMCID:PMC1838958)

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By combining crystallographic information with protein-interaction data obtained through traditional experimental means, this paper determines the most appropriate method for generating protein-interaction networks that incorporate data derived from protein complexes. We propose that a combined method should be considered; in which complexes composed of five chains or less are decomposed using the matrix model, whereas the spoke model is used to derive pairwise interactions for those with six chains or more. The results presented here should improve the accuracy and relevance of studies investigating the topology of protein-interaction networks.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Robertson, Professor David
Authors: Hakes, L., Robertson, D. L., Oliver, S. G., and Lovell, S. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Comparative and Functional Genomics
Publisher:Hindawi Publishing Corporation
ISSN (Online):1531-6268
Copyright Holders:Copyright © 2007 Luke Hakes et al.
First Published:First published in Comparative and Functional Genomics 2007: 49356
Publisher Policy:Reproduced under a Creative Commons License

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