Immune checkpoint inhibitors: new strategies to checkmate cancer

Wilson, R. A.M., Evans, T.R. J. , Fraser, A. R. and Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191(2), pp. 133-148. (doi: 10.1111/cei.13081) (PMID:29139554)

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Immune checkpoint inhibitors (ICIs) targeting Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) or Programmed cell Death protein 1 (PD-1) receptors have demonstrated remarkable efficacy in subsets of patients with malignant disease. This emerging treatment modality holds great promise for future cancer treatment and has engaged pharmaceutical research interests in tumour immunology. While ICIs can induce rapid and durable responses in some patients, identifying predictive factors for effective clinical responses has proven challenging. This review summarises the mechanisms of action of ICIs and outlines important pre-clinical work that contributed to their development. We explore clinical data that has led to disease-specific drug licensing, and highlight key clinical trials that have revealed ICI efficacy across a range of malignancies. We describe how ICIs have been used as part of combination therapies, and explore their future prospects in this area. We conclude by discussing the incorporation of these new immunotherapeutics into precision approaches to cancer therapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Wilson, Dr Ruairi and Fraser, Dr Alasdair and Evans, Professor Jeff and Nibbs, Professor Rob
Authors: Wilson, R. A.M., Evans, T.R. J., Fraser, A. R., and Nibbs, R. J.B.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Clinical and Experimental Immunology
ISSN (Online):1365-2249
Published Online:15 November 2017
Copyright Holders:Copyright © 2017 British Society for Immunology
First Published:First published in Clinical and Experimental Immunology 191(2): 133-148
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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