The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation

Stoumpos, S., Lees, J. , Welsh, P. , Hund, M., Geddes, C. C., Nelson, S. M. and Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36(2), pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003) (PMID:29233504)

Abstract

Women with renal disease have menstrual and gonadal dysfunction manifesting as hormonal imbalance. Anti-Müllerian hormone (AMH) is a potential measure of ovarian reserve. We examined circulating AMH concentrations in young women with renal failure, determined associations with clinical characteristics, and compared AMH with age-matched healthy individuals. AMH was measured in 77 women: 26 had chronic kidney disease (CKD), 26 were on haemodialysis (HD), and 25 had a kidney transplant. Random AMH levels were highest in women on HD [HD 2.9 (1.1–5.2), CKD 1.6 (0.7–2.2), transplant 1.5 (1.0–4.2) ng/ml]. On multiple linear regression, AMH was 53% higher [95% CI 0.20–0.98, P = 0.002] in women on HD and decreased by 20% per 5-year increase in age (P < 0.001). AMH was 43% lower in women with renal failure compared with 600 age-matched controls [1.7 (0.9–3.8) versus 3.0 (1.9–5.0) ng/ml, P < 0.001]; however, we found no difference in AMH between those on HD and healthy individuals [2.9 (1.1–5.2) versus 3.0 (1.9–5.0) ng/ml]. AMH may be a useful biomarker in female renal patients with non-dialysis dependent renal disease pursuing pregnancy. In contrast, AMH levels are higher in HD but unlikely to reflect ovarian reserve.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Nelson, Professor Scott and Lees, Jennifer and Mark, Professor Patrick and Welsh, Professor Paul and Stoumpos, Dr Sokratis and Geddes, Dr Colin
• Authors: Stoumpos, S., Lees, J., Welsh, P., Hund, M., Geddes, C. C., Nelson, S. M., and Mark, P. B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Reproductive BioMedicine Online
• Publisher: Elsevier
• ISSN: 1472-6483
• ISSN (Online): 1472-6491
• Published Online: 28 November 2017
• Copyright Holders: Copyright © 2017 Reproductive Healthcare Ltd
• First Published: First published in Reproductive BioMedicine Online 36(2):219-226
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.