The susceptibility of BALB/C and other inbred mouse strains to Brugia pahangi

Howells, R.E., Devaney, E. , Smith, G. and Hedges, T. (1983) The susceptibility of BALB/C and other inbred mouse strains to Brugia pahangi. Acta Tropica, 40(4), pp. 341-350. (PMID:6142632)

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The susceptibility of several strains of inbred mice to infection with the filarial worm Brugia pahangi has been examined. BALB/C, C57BL/10, C3H/He, 101, CBA/Ca mice, congenitally asplenic (DH/+) mice and their normal litter-mates (+/+) were each challenged by the intraperitoneal inoculation of 50 infective larvae. During the first four weeks of infection high (19-42%) larval recoveries were obtained from the CBA/Ca, BALB/C and Dh/+ mice but fewer than 10% of inoculated larvae were recovered from C3H/He, 101; C57BL/10 and +/+ mice. Larval growth rates in all mice were similar. BALB/C and Dh/+ mice only were examined later than four weeks after infection. The yield of adult worms from BALB/C was 7.5% at 16 weeks and from Dh/+ 4.2% at 21 weeks. Microfilariae were present in the peritoneal fluids but not the blood of some mice harbouring both adult male and female worms.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen
Authors: Howells, R.E., Devaney, E., Smith, G., and Hedges, T.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Acta Tropica
ISSN (Online):1873-6254

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