Brun, O., Archibald, L. J., Agramunt, J., Pedroso, E. and Grandas, A. (2017) Simultaneous cyclization and derivatization of peptides using cyclopentenediones. Organic Letters, 19(5), pp. 992-995. (doi: 10.1021/acs.orglett.6b03825) (PMID:28212041)
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Abstract
Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction times using only a slight excess of the cyclopentenedione moiety under TEMPO catalysis and in the presence of LiCl.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Archibald, Dr Lewis |
| Authors: | Brun, O., Archibald, L. J., Agramunt, J., Pedroso, E., and Grandas, A. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic Letters |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| ISSN (Online): | 1523-7052 |
| Published Online: | 17 February 2017 |
| Copyright Holders: | Copyright © 2017 American Chemical Society |
| First Published: | First published in Organic Letters 19(5): 992-995 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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