Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi: 10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)
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Abstract
The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti. Here we analysed the competence of Cx. quinquefasciatus (with or without Wolbachia endosymbionts) for a ZIKV isolate. We also examined the induction of RNA interference pathways after viral challenge and the production of small virus-derived RNAs. We did not observe any infection nor such small virus-derived RNAs, regardless of the presence or absence of Wolbachia. Thus, Cx. quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. In short, these mosquitoes are very unlikely to play a role in transmission of ZIKV.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vattipally, Dr Sreenu and Varjak, Dr Margus and Kohl, Professor Alain |
| Authors: | Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B., Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M., Kohl, A., and Failloux, A.-B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Journal of General Virology |
| Publisher: | Microbiology Society |
| ISSN: | 0022-1317 |
| ISSN (Online): | 1465-2099 |
| Published Online: | 27 October 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Journal of General Virology 99:258-264 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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