Feng, Y.-M. et al. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33(3), pp. 426-435. (doi: 10.1093/ndt/gfx256) (PMID:28992257)
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Abstract
Background. Inflammation is a hallmark of chronic kidney disease (CKD) and stimulates glomerular expression of vascular adhesion molecules (VCAMs). We investigated in a general population whether estimated glomerular filtration rate (eGFR) is associated with circulating adhesion molecules, inflammation markers or both. Methods. We measured serum levels of five adhesion molecules [VCAM-1, intracellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin and monocyte chemoattractant protein-1 (MCP-1)] and seven inflammation markers [C-reactive protein (CRP), neutrophil gelatinase-associated lipocalin (NGAL), tumour necrosis factor receptor 1 (TNF-R1), TNF-α, interleukin 6 (IL-6), IL-8 and vascular endothelial growth factor] in 1338 randomly recruited people (50.8% women, mean age 51.7 years, eGFR 79.9 mL/min/1.73 m2). Results. In multivariable-adjusted analyses, eGFR decreased (P ≤ 0.004) with higher VCAM-1 (association size expressed in mL/min/1.73 m2 for a doubling of the marker, −2.99), MCP-1 (−1.19), NGAL (−1.19), TNF receptor 1 (−2.78), TNF-α (−2.28) and IL-6 (−0.94). The odds ratios of having eGFR <60 versus ≥60 mL/min/1.73 m2 (n = 138 versus 1200) were significant (P ≤ 0.001) for VCAM-1 (1.77), MCP-1 (1.32), NGAL (1.26), TNF-R1 (1.49), TNF-α (1.45) and IL-6 (1.20). Compared with 24-h albuminuria, VCAM-1 increased (P <0.0001) the area under the curve from 0.57 to 0.65, MCP-1 to 0.67 and TNF-R1 to 0.79, but TNF-R1 outperformed both adhesion molecules (P < 0.0001). Conclusions. In a general population, eGFR is inversely associated with circulating adhesion molecules VCAM-1 and MCP-1 and several inflammation markers, but inflammation markers, in particular TNF-R1 and TNF-α, identify patients with eGFR <60 mL/min/1.73 m2 more accurately.
| Item Type: | Articles |
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| Keywords: | Adhesion molecules, eGFR, inflammation, population science, renal function. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dominiczak, Professor Anna and Delles, Professor Christian |
| Authors: | Feng, Y.-M., Thijs, L., Zhang, Z.-Y., Yang, W.-Y., Huang, Q.-F., Wei, F.-F., Kuznetsova, T., Jennings, A.-M., Delles, C., Lennox, R., Verhamme, P., Dominiczak, A., and Staessen, J. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Nephrology Dialysis Transplantation |
| Publisher: | Oxford University Press |
| ISSN: | 0931-0509 |
| ISSN (Online): | 1460-2385 |
| Published Online: | 23 August 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Nephrology Dialysis Transplantation 33(3):426-435 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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